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Introducing Restylane Refyne and Defyne

Posted on: February 1st, 2017 by California Skin Institute

Have you heard about Restylane Refyne and Restylane Defyne? These fillers were just approved by the FDA in December 2016, and California Skin Institute is one of the first dermatology practices in the United States to offer treatments with these injectables, starting in February 2017!*

Both Restylane Refyne and Defyne are manufactured by Galderma, and are part of the company’s broader range of dermal fillers, which also include well-known treatments like Restylane, Restylane Silk, and Restylane Lyft.

How are Restylane Refyne and Defyne Used?

One of the common issues that occurs with aging is the lack of support under the skin. It happens because the collagen support network becomes weaker (thus leading to laxity), and the creases from constant facial expressions begin to take a permanent hold – even when your face is completely relaxed.

Restylane Refyne and Defyne were developed to treat such wrinkles and facial lines, especially those that are deep and severe.* A great example of these is nasolabial folds.* These run from the corners of the nose to the corners of the mouth and can make you look much older than you really are by simply creating unflattering shadows that change the perception of facial contour.

Fillers like Restylane Refyne and Defyne can address these wrinkles by giving your skin much-needed support in key areas.*

When injected into the treatment site, the gel-like texture of these fillers gives the skin immediate support, which makes the wrinkle less visible.* Then, the hyaluronic acid goes to work by attracting moisture to the treatment site and helping the improvements last much longer.*

Hyaluronic Acid: the Key Ingredient in Restylane Refyne and Defyne

At the core, Restylane Refyne and Defyne work by utilizing the hydrophilic properties of hyaluronic acid.* This chemical is great at attracting, and holding on to, moisture.* And because it’s also made by our bodies, it’s unlikely to cause serious side effects.*

However, it’s also important to note that hyaluronic acid goes beyond improving the longevity of dermal fillers.* By drawing moisture to the treatment site, it helps the surrounding skin cells and fibroblasts get the much-needed hydration for proper function.*

Restylane Refyne vs. Defyne: What’s the difference?

Both Restylane Refyne and Defyne were developed with moderate to severe wrinkles in mind, and both can be used to address nasolabial folds.* They are an outgrowth of the company’s Emervel brand, which has been successfully used in Europe to help patients achieve their aesthetic goals.*

What makes these two fillers so special is the difference in how the chains of hyaluronic acid molecules are cross-linked.* Both utilize something called XpressHAn technology, which focuses on giving the fillers more flexibility, so that they feel more natural under the skin.* However, the cross linking structure is somewhat different for Refyne and Defyne. Let’s take a closer look at how this affects their use:

  • Restylane Refyne:  Galderma formulated this filler with the idea of motion and flexibility.* As such, it’s considered to be a “dynamic” filler that is primarily used on areas of the face where a lot of motion occurs – like around the mouth.* Restylane Refyne is meant to reduce the appearance of wrinkles while allowing for the skin to flex very naturally when making facial expressions.*
  • Restylane Defyne:  This filler places a greater emphasis on supporting the skin, and is meant to enhance areas that where expressions are less likely to occur.* Thus it can be used on parts of the face that have experienced subtle volume loss, for subtle improvements in contour and deep wrinkles.*

Restylane Refyne and Defyne Results

The results from both of these fillers are virtually instantaneous.* Because of the gel-like consistency, the fillers look and feel very natural under the skin.*

In terms of longevity, the results will last up to 12 months after the injection.*1

Restylane Refyne and Defyne Side Effects

As with any injectable treatment, there is bound to be slight swelling and redness at the treatment site after the injection.* This is due to your body’s natural defense and self repair mechanisms. However, these Restylane treatments have no associated down time and any redness should subside within a few days and are typically easily covered with makeup.*

Your Restylane Refyne and Defyne Consultation

Take advantage of introductory Restylane Refyne and Defyne pricing at California Skin Institute! Schedule your appointment by calling a CSI practice near you or use the online scheduling portal now.

References: 1. A 12-Month Follow-up, Randomized Comparison of Effectiveness and Safety of Two Hyaluronic Acid Fillers for Treatment of Severe Nasolabial Folds. Benjamin Ascher, MD,corresponding author* Christiane Bayerl, MD, Philippe Kestemont, MD, Berthold Rzany, MD, ScM, Carolina Edwartz, PhD, and Maurizio Podda, MD 2017

*Individual results may vary and are not guaranteed.